SHORT REPORT Support of the histaminergic hypothesis in Tourette Syndrome: association of the histamine decarboxylase gene in a large sample of families
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چکیده
Support of the histaminergic hypothesis in Tourette Syndrome: association of the histamine decarboxylase gene in a large sample of families Iordanis Karagiannidis, Sandra Dehning, Paul Sandor, Zsanett Tarnok, Renata Rizzo, Tomasz Wolanczyk, Marcos Madruga-Garrido, Johannes Hebebrand, Markus M Nöthen, Gerd Lehmkuhl, Luca Farkas, Peter Nagy, Urszula Szymanska, Zachos Anastasiou, Vasileios Stathias, Christos Androutsos, Vaia Tsironi, Anastasia Koumoula, Csaba Barta, Peter Zill, Pablo Mir, Norbert Müller, Cathy Barr, Peristera Paschou
منابع مشابه
Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families.
BACKGROUND Gilles de la Tourette Syndrome is a neurodevelopmental disorder that is caused by the interaction of environment with a complex genetic background. The genetic etiology of the disorder remains, so far, elusive, although multiple promising leads have been recently reported. The recent implication of the histamine decarboxylase (HDC) gene, the key enzyme in histamine production, raises...
متن کاملDeletion of histidine decarboxylase (HDC) enhances the antinociceptive effects of orexin A in the central nervous system
It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...
متن کاملDeletion of histidine decarboxylase (HDC) enhances the antinociceptive effects of orexin A in the central nervous system
It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...
متن کاملCo-Morbidity of Attention Deficit Hyperactivity Disorder (ADHD) and Tourette Syndrome in Child Referral Psychiatry Clinic in Iran
Objectives: Tourette syndrome is a disorder with motor and vocal tics, which has many psychiatric comorbidities. Attention Deficit Hyperactivity Disorder (ADHD) is one of co-morbid features of this syndrome. The aim of this research is studying Tourette and co morbidity ADHD in school age children. One of our purposes is to identify the range of ADHD in Iranian Tourette patients. Methods: Th...
متن کاملHistamine modulation of the basal ganglia circuitry in the development of pathological grooming.
Aberrant histaminergic function has been proposed as a cause of tic disorders. A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS). Hdc knockout mice exhibit repetitive behavioral pathology and neurochemical characteristics of TS, establishing them as a plausible model of tic pathophysiology. Wher...
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تاریخ انتشار 2013